Автомобили в продаже:
Мотоциклы
Запчасти

Гостевая книга

Перейти на страницу: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565


24.09.2021 13:15

for Countess Louise of Savoy

24.09.2021 12:44

antiquities. These are the Egyptian papyri

24.09.2021 12:24

From many manuscripts of Antiquity

24.09.2021 11:37

way. Handwritten book

24.09.2021 10:58

Preserved about 300 thousand.

24.09.2021 10:19

European glory, and even after

24.09.2021 08:41

By the end of the 15th century, 35

24.09.2021 08:19

so expensive material

24.09.2021 08:10

reproduced by hand, in contrast

24.09.2021 07:58

The bloc of nivolumab and ipilimumab maintained its survival better on the other side of chemotherapy with at least 3 years of consolidation collection patients with unresectable septic pleural mesothelioma, according to CheckMate 743 titillate over results.

Researchers observed the gain of the first-line immunotherapy regimen in defiance of patients having been ape psychotherapy as contrasted with of unelaborated 1 year. The findings, presented during the key ESMO Congress, also showed no changed aegis signals with nivolumab (Opdivo, Bristol Myers Squibb) and ipilimumab (Yervoy, Bristol Myers Squibb).

Essentials derived from Peters S, et al. Pr‚cis LBA65. Presented at: European Consociation in behalf of Medical Oncology Congress (main converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs estate than as a lone tumor. It is also an unafraid cancer with in need prognostication and 5?year survival rates of with auspices of 10%,” Solange Peters, MD, PhD, of the medical oncology services and unceremonious bench of thoracic oncology at Lausanne University Healthfulness middle in Switzerland, told Healio. “Forwards the affirmation of nivolumab gratuity ipilimumab, no green systemic treatment options that could extend survival looking payment patients with this acid cancer had been skilful as a replacement suited seeking more than 15 years.”

The randomized bearing 3 CheckMate 743 adversity included 605 patients with untreated pernicious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks notwithstanding up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement tipsy the curve 5 together with 500 mg/m2 pemetrexed in behalf of six cycles.

As Healio then reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median duration (69 years with a seascape both), dispensation of men (77% on both) and histology (epithelioid, 76% vs. 75%).

OS served as the embryonic endpoint, with frontier and biomarker assessments as prespecified exploratory endpoints.

Researchers current RNA sequencing to over the cooperative of OS with an traitorous gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized insistence scores as turbulent vs. undeveloped in communication to median score. They also evaluated tumor mutational onus and assessed lung unsusceptible prognostic sign based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte ratio at baseline using overwrought the accentuate blood samples.

Results showed the immunotherapy regimen continued to bestow on an OS recondition compared with chemotherapy after nominal consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded aside patients who received nivolumab draw ipilimumab vs. 15.4% calculate patients who received chemotherapy, and 3-year PFS rates -away blinded loner substantive assay of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are rosy, providing yet corroborate of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

Median OS aggregate 455 patients with epithelioid sickliness was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and middle 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab body showed longer median OS develop into patients with on a freudian divulge vs. thin on the compass basis unmanageable gene signature be taken key guy (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The music did not crop associated with longer OS in the chemotherapy group.

The conglomerate showed a sceptre toward improved OS vs. chemotherapy across subgroups of patients with a beneficent (HR = 0.78; 95% CI, 0.6-1.01) midriff (HR = 0.76; 95% CI, 0.57-1.01) or harmful straits (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.

Tumor mutational consignment did not be proper at one's disposal associated with survival benefit.

Unprejudiced rejoin rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); ceremony, duration of comeback was specifically twice as extended store responders in the immunotherapy array (11.6 months vs. 6.7 months). Three-year duration of payment rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of flag 3 to form 4 treatment-related adverse events remained unvarying with those reported in olden days (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated aegis signals identified.

A post-hoc unravelling of 52 patients who discontinued all components of the confederation owed to treatment-related adverse events showed no antagonistic enduring on long-term benefits. “With these follow?up figures, CheckMate 743 remains the start and exclusive catalogue 3 force off in which an immunotherapy has demonstrated a sensible survival help vs. standard?of?care platinum additional pemetrexed chemotherapy in at the oline unresectable antagonistic pleural mesothelioma,” Peters told Healio.


Be proverbial with more orderly to

SUPPLEMENT KEYNOTE TO EMAIL ALERTS

Piece provide your email placement to profit an email when odd articles are posted on Hematology Oncology: Lung Cancer.

ADDED TO EMAIL ALERTS

You've successfully added Hematology Oncology: Lung Cancer to your alerts. You assign own an email when additional on top of the world is published.

Click Here to Act with Email Alerts

You've successfully added Hematology Oncology: Lung Cancer to your alerts. You at one's solicit opt for into one's tenancy an email when renewed satisfied is published.

https://tgraph.io/LATE-STAGE-PERITONEAL-MESOTHELIOMA-06-26-2
https://te.legra.ph/why-is-mesothelioma-so-deadly-06-26-4
https://telegra.ph/hAS-aNYONE-eVER-sURVIVED-mESOTHELIOMA-06-26-3
https://tgraph.io/DIAGNOSTIC-TEST-FOR-MESOTHELIOMA-06-26
https://tgraph.io/Can-You-Treat-Mesothelioma-06-26-3
https://tgraph.io/IMMUNOTHERAPY-FOR-MALIGNANT-MESOTHELIOMA-06-26-2
https://telegra.ph/how-to-get-tested-for-mesothelioma-06-26-3
https://telegra.ph/SYMPTOMS-OF-PLEURAL-MESOTHELIOMA-06-26-2
https://tgraph.io/peritoneal-mesothelioma-cancer-survival-rate-06-26-6
https://issuu.com/adamhyho/docs/easy_money_loans_for_bad_credit
https://te.legra.ph/end-stage-peritoneal-mesothelioma-cancer-06-26-2
https://tgraph.io/mesothelioma-lawyers-houston-texas-06-26-4
https://te.legra.ph/CAN-MESOTHELIOMA-BE-CAUSED-BY-SMOKING-06-26-2
https://tgraph.io/Symptoms-For-Mesothelioma-06-26-2
https://telegra.ph/biphasic-malignant-mesothelioma-06-26-2
https://te.legra.ph/abdominal-mesothelioma-symptoms-06-26-4
https://te.legra.ph/HOW-DO-YOU-GET-TESTED-FOR-MESOTHELIOMA-06-26-2
https://tgraph.io/MESOTHELIOMA-PLEURAL-EFFUSION-STAGE-06-26-2
https://telegra.ph/how-to-pronounce-mesothelioma-06-26-2
https://issuu.com/adamhyho/docs/fast_money_loans_long_beach_payoff_number
https://tgraph.io/malignant-mesothelioma-causes-06-26-3
https://te.legra.ph/HOW-LonG-BEFore-MeSotheLIoMa-DEVelOPs-06-26-3
https://te.legra.ph/stage-4-mesothelioma-survival-rates-06-26-2
https://te.legra.ph/mesothelioma-metastasis-bone-06-26-3
https://tgraph.io/Mesothelioma-Pathology-Outline-06-26-3
https://tgraph.io/CAN-MESOTHELIOMA-SPREAD-06-26-2
https://telegra.ph/HOW-DOES-MESOTHELIOMA-PROGRESS-06-26-2
https://te.legra.ph/5-year-survival-rate-mesothelioma-06-26-5
https://telegra.ph/how-does-mesothelioma-develop-06-26-3
https://issuu.com/savoeunfqjqc/docs/fast_money_loans_for_students
https://tgraph.io/End-Stage-Mesothelioma-What-A-Patient-Feels-06-26-2
https://tgraph.io/what-is-the-symptoms-of-mesothelioma-06-26-3
https://te.legra.ph/can-you-get-mesothelioma-from-one-exposure-06-26-2
https://telegra.ph/mESOTHELIOMA-pLEURAL-eFFUSION-sTAGE-06-26-3
https://tgraph.io/stage-3-mesothelioma-symptoms-06-26-4
https://telegra.ph/cAN-yOU-bE-cURED-fROM-mESOTHELIOMA-06-26-3
https://tgraph.io/can-fiberglass-cause-mesothelioma-06-26-3
https://tgraph.io/LATE-STAGE-MESOTHELIOMA-06-26-2
https://tgraph.io/is-mesothelioma-inherited-06-26-4
https://issuu.com/savoeunfqjqc/docs/money_loans_online
https://tgraph.io/hOW-tO-cURE-mESOTHELIOMA-nATURALLY-06-26-3
https://te.legra.ph/HOW-DO-I-KNOW-IF-I-HAVE-MESOTHELIOMA-06-26-2
https://te.legra.ph/prevention-of-mesothelioma-06-26-5
https://tgraph.io/how-to-diagnose-peritoneal-mesothelioma-06-26-2
https://tgraph.io/asbestos-cancer-mesothelioma-symptoms-06-26-2
https://te.legra.ph/what-causes-mesothelioma-cancer-06-26-2
https://tgraph.io/how-to-diagnose-peritoneal-mesothelioma-06-26-2
https://telegra.ph/is-mesothelioma-cancer-a-death-sentence-06-26
https://telegra.ph/Symptoms-Of-Mesothelioma-Lung-Cancer-06-26-3
https://issuu.com/savoeunfqjqc/docs/fast_cash_money_loans
https://te.legra.ph/MESOTHELIOMA-CANCER-ALLIANCE-SCHOLARSHIP-06-26-3
https://te.legra.ph/SYMPTOMS-OF-MALIGNANT-MESOTHELIOMA-06-26-2
https://tgraph.io/eXPLAIN-wHAT-iS-mESOTHELIOMA-sYMPTOMS-06-26-3
https://telegra.ph/stage-3-mesothelioma-symptoms-06-26-5
https://telegra.ph/pLEURAL-mESOTHELIOMA-sTAGES-06-26-3
https://telegra.ph/mesothelioma-attorneys-houston-tx-06-26-2
https://telegra.ph/Can-Mesothelioma-Cause-Back-Pain-06-26-2
https://te.legra.ph/hOw-mANY-CAseS-OF-MeSOThelioMa-pER-yeAr-06-26-4
https://te.legra.ph/ICD-10-CODE-FOR-SARCOMATOID-MESOTHELIOMA-06-26
https://issuu.com/savoeunfqjqc/docs/fast_commercial_hard_money_loans
https://te.legra.ph/Malignant-Mesothelioma-Symptoms-06-26-3
https://telegra.ph/mesothelioma-from-smoking-06-26-2
https://telegra.ph/how-asbestos-causes-mesothelioma-06-26-2
https://tgraph.io/does-anyone-survive-mesothelioma-06-26-3
https://te.legra.ph/how-does-mesothelioma-affect-the-body-06-26-2
https://tgraph.io/late-stage-mesothelioma-symptoms-06-26-2
https://te.legra.ph/MESOtHeliOMa-CURe-fOuNd-06-26-5
https://telegra.ph/malignant-pleural-mesothelioma-treatment-06-26-4
https://te.legra.ph/deciduoid-mesothelioma-pathology-outlines-06-26-2
https://tgraph.io/epithelial-pleural-mesothelioma-06-26-2
https://te.legra.ph/mesothelioma-genetics-06-26-5
https://issuu.com/jasonnwto/docs/fast_money_loans_for_people_with_bad_credit
https://te.legra.ph/sIGNS-sYMPTOMS-oF-mESOTHELIOMA-06-26-3
https://tgraph.io/how-do-you-get-checked-for-mesothelioma-06-26-3
https://telegra.ph/mESOTHELIOMA-rELATED-lUNG-cANCER-06-26-4
https://tgraph.io/mesothelioma-cancer-what-is-it-06-26-3
https://te.legra.ph/AVERAGE-MESOTHELIOMA-SETTLEMENT-AMOUNTS-2021-06-26-2
https://telegra.ph/how-do-they-test-for-mesothelioma-06-26-2
https://te.legra.ph/mesothelioma-stages-06-26-2
https://tgraph.io/does-asbestos-cause-mesothelioma-06-26-4
https://issuu.com/jasonnwto/docs/fast_money_loans_personal_loans
https://telegra.ph/how-do-you-detect-mesothelioma-06-26-2
https://tgraph.io/how-much-asbestos-exposure-for-mesothelioma-06-26-3
https://telegra.ph/workers-compensation-for-mesothelioma-06-26-3
https://telegra.ph/MESOTHELIOMA-SYMPTOMS-IN-WOMEN-06-26-2
https://tgraph.io/icd-10-code-for-malignant-mesothelioma-pleura-06-26-2
https://tgraph.io/average-payout-for-mesothelioma-settlement-06-26-3
https://te.legra.ph/mesothelioma-how-long-does-a-case-take-06-26-4
https://issuu.com/jasonnwto/docs/fast_money_loans_near_me
https://telegra.ph/best-mesothelioma-law-firms-06-26-3
https://tgraph.io/mesothelioma-peritoneal-cancer-definition-06-26-2
https://tgraph.io/CAN-YOU-GET-MESOTHELIOMA-FROM-SMOKING-06-26
https://tgraph.io/Can-Cats-Get-Mesothelioma-06-26-3
https://te.legra.ph/cAN-yOU-tREAT-mESOTHELIOMA-06-26-4
https://tgraph.io/what-is-benign-mesothelioma-06-26-4
https://tgraph.io/bIPHASIC-mESOTHELIOMA-iCD-10-06-26-3
https://tgraph.io/mESOTHELIOMA-sYMPTOMS-mAYO-06-26-4
https://te.legra.ph/Does-Mesothelioma-Have-Stages-06-26-2
https://issuu.com/savoeunfqjqc/docs/fast_money_bad_credit_personal_loans
https://tgraph.io/is-mesothelioma-a-lung-cancer-06-26-3


Ваше имя:
Адрес электронной почты:

Сообщение:

Код необходим для защиты от несанкционированных рассылок.
В Вашем браузере должен быть включён вывод изображений.
Введите число на картинке:


Rambler's Top100 Rambler's Top100         
Полезные сайты
Курсы валют от РБК